The Vindice Water Prison, located in Europe, suspends those contained in the lowest sections of the prison in water, making the contained person completely immobile; as such, all their muscle mass is removed and it is said that no sound nor light can ever reach those who are imprisoned here. However, Mukuro has shown the ability to use Illusions even inside his cell, and Demon Spade was able to escape when he possessed Mukuro's body.
Although the prisoners are doomed to live the rest of their lives in this dreadful prison, if their allies can make the right kind of deal, it is possible that their release can be negotiated.
- Even Byakuran was unwilling to go against the Vindice to release Ghost, instead of sending Iris to negotiate Ghost's release, a testament to their fearful reputation.
- This prison is also called "Iron Wall," as told by Levi.
- Vindice Prison is revealed to be provided with security cameras both inside and outside prison cells and alarms that alert the Vindice to escaping prisoners, just like ordinary prisons.