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Nana Sawada (沢田 奈々, Sawada Nana) is Tsunayoshi Sawada's mother, who, despite caring deeply for him, has fairly little belief in her son succeeding in life. She does not expect him to get into a good college, has an outburst claiming that her son is a loser, is eternally grateful for Haru wanting to be his girlfriend despite how pathetic he is in her eyes, etc. She helps feed all the people that are presently living in her house and does not see anything strange with any of them. She, on the surface, seems to be unaware of the fact that both her husband and her son are part of the Mafia, though at times this is called into question.
Nana first appeared finding out about Reborn's letter of being a home tutor. She's often being seen cooking and running errands for the family. Reborn, Bianchi, Lambo, I-Pin, Fuuta, and Dino call her Mama.
Nana is oblivious about Tsuna and his friends' fight with the Varia and is seen to be very happy after her husband, Iemitsu comes home. She stays at the hospital where Lambo is charged after the Lightning Ring Battle, worrying over Lambo's condition.
In the Future Arc, she was revealed to be on vacation with her husband in Italy when the Millefiore Famiglia attacked the Vongola Headquarters; her condition in the Future was unknown after that.
Nana is first seen reprimanding Tsuna for stating to his father Iemitsu that whenever he came home, things got weird. Nana then goes on to meet with Iemitsu's CEDEF subordinates, whom he introduces as his "fellow workers" when digging for oil, also happily agreeing to let them stay at their house. When Byakuran arrives and flies up to Tsuna's balcony on the second floor, Nana remains oblivious and wonders if it was a magic trick. When the Vindice attacked team Collonello at Tsuna's house, Nana came out telling Iemitsu that he would disturb the neighbors with the noise he was making. The Vindice then attacked her.
- In the Reborn! Fandom, her number is 77.
- When Spanner was the guest at the Haru Haru's Interview: Dangerous, he was looking for a Yamato Nadeshiko (a woman with a gentle heart). Reborn said that there's only one woman he knows that fits said description and it was Nana Sawada, even though Haru had been hoping to be the one.
- She has shown frustration at being kept in the dark by her husband and son.
- She had long hair when Tsuna was still young.
- Before her marriage, she was working as a waitress.
- Lambo is only able to activate his Cambio Forma when he misses Nana, evidencing Lambo's devotion to Nana.
- Tsuna seems to have inherited more of his mother's looks (as noted by Timoteo in the anime).
- She is referred to as Mama by Reborn, Fuuta, Dino, I-Pin, Bianchi, Gokudera, and Lambo.
- Nana and Iemitsu are ranked first as a "loving married couple" by Fuuta.
- Fuuta's rankings shows that Nana's omelettes are first-rate.